Quantitative muscle ultrasonography using textural analysis in amyotrophic lateral sclerosis
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Author/sMartínez Payá, Jacinto Javier
Terapia y Rehabilitación
Subject/sAmyotrophic lateral sclerosis
Area under the curve
Background: To analyze differences in grey level co-ocurrence matrix (GLCM) parameters, as assessed by muscle ultrasound (MUS), between amyotrophic lateral sclerosis (ALS) patients and healthy controls. To compare the diagnostic accuracy of these GLCM parameters with first order MUS parameters (echointensity, EI; echovariation, EV; and muscle thickness, MTh) in different muscle groups. Methods: Twenty-six patients with ALS and twenty-six healthy subjects underwent bilateral and transverse ultrasound of the biceps/brachialis, forearm flexor, quadriceps femoris and tibialis anterior muscle groups. MTh was measured with electronic callipers and EI, EV and GLCM were obtained using Image J (v.1.48) software. Sensitivity, specificity, likelihood ratios and area under the curve (AUC) were performed by logistic regression models and ROCcurves. Results: GLCM parameters showed reduced granularity in the muscles of ALS patients compared with the controls. Regarding the discrimination capacity, t...