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dc.contributor.authorMartínez Payá, Jacinto Javier
dc.contributor.otherdel Baño-Aledo, María Elena
dc.contributor.otherRíos-Díaz, José
dc.contributor.otherTembl-Ferrairó, José Ignacio
dc.contributor.otherVázquez-Costa, Juan Francisco
dc.contributor.otherMedina-Mirapeix, Francesc
dc.date.accessioned2017-05-04T13:12:40Z
dc.date.available2017-05-04T13:12:40Z
dc.date.issued2017
dc.identifier.issn0301-5629
dc.identifier.urihttp://hdl.handle.net/10952/2281
dc.description.abstractThe purpose is to assess the characteristics of echovariation in amyotrophic lateral sclerosis (ALS) compared with other MUS parameters. Twenty-six ALS patients (8 women, mean age 58.9 years, SD 12.02 yr) and 26 healthy controls (17 women; mean age 59.6 years, SD 6.41 yr) were included in this observational study. They underwent bilateral and transverse ultrasound of the biceps/brachialis, forearm flexor group, quadriceps femoris and tibialis anterior. Muscular thickness, echointensity and echovariation were analyzed. Muscles affected by ALS showed increased echointensity, decrease in thickness, and decrease echovariation. Echovariation in all muscles but quadriceps femoris, strongly correlated with muscle strength (explained variance between 21.8% in the biceps/brachialis and 37.5% in tibialis anterior) and the ALSFRS-R score (explained variance between 26% in the biceps/brachialis and 36.7% in the forearm flexor group). Echovariation is an easy to obtain QMUS parameter that could distinguish ALS from healthy controls more accurately than previous described biomarkers.es
dc.description.sponsorshipUCAMes
dc.language.isoenes
dc.publisherElsevieres
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectClinical neurology examinationes
dc.subjectObservational studyes
dc.subjectUltrasoundes
dc.subjectAmyotrophic lateral sclerosises
dc.titleMuscular echovariation: a new biomarker in amyotrophic lateral sclerosises
dc.typearticlees
dc.rights.accessRightsopenAccesses
dc.journal.titleUltrasound in Medicina & Biologyes
dc.volume.number1es
dc.issue.number1es
dc.description.disciplineMedicinaes
dc.description.disciplineTerapia y Rehabilitaciónes


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional