Effect of a Combination of Citrus Flavones and Flavanones and Olive Polyphenols for the Reduction of Cardiovascular Disease Risk: An Exploratory Randomized, Double-Blind, Placebo-Controlled Study in Healthy Subjects
Ficheros
Compartir
Estadísticas
Ver Estadísticas de usoMetadatos
Mostrar el registro completo del ítemAutor/es
Sánchez Macarro, Maravillas; Martínez Rodríguez, Juan Pablo; Bernal Morell, Enrique; Pérez Piñero, Silvia; Victoria Montesinos, Desirée; [et al.]Fecha
2020-05-19Disciplina/s
Ciencias de la AlimentaciónFarmacia
Medicina
Materia/s
Bitter orangeCardiovascular risk
Secoiridoids
Olive
Grapefruit
Endothelial function
Citrus flavonoids
Polyphenols
Resumen
A single-center, randomized, double-blind controlled trial was conducted to assess the efficacy of a food supplement based on a combination of grapefruit, bitter orange, and olive extracts administered for eight weeks (n = 51) versus placebo (n = 45) on reduction of cardiovascular risk in healthy volunteers. Study variables included flow-mediated vasodilation (FMD), blood pressure (BP), lipid profile, thrombotic status, oxidative stress biomarkers, inflammation-related biomarkers, anthropometric variables, quality of life, and physical activity. The per-protocol data set was analyzed. In the active product group, there were statistically significant within-group differences at eight weeks as compared with baseline in FMD, systolic and diastolic BP, total cholesterol, LDL-C, LDL-oxidase, oxidized/reduced glutathione ratio, protein carbonyl, and IL-6. Significant between-group differences in these variables were also found. Significant changes in anthropometric variables and quality of l...