Prospective Clinical Study with New Materials for Tissue Regeneration: A Study in Humans
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Author/sKollek, Nathalie Jeannette
Director/sMaté Sánchez de Val, José Eduardo
Subject/sBone graft substitute
Objective: This study was performed to evaluate the clinical, radiographic, and histomorphometric outcomes of novel bone grafting materials and dental membranes and to compare the results with current data from literature. Materials and Methods: New synthetic bone substitutes, consisting of biphasic calcium phosphate, in the ratio of 60% hydroxyapatite and 40% β-tricalcium phosphate, were applied in bony defects and covered by either a novel synthetic poly(lactic-co-glycolic) acid (PLGA) or porcine collagen membrane. A sample of 51 biomaterials was placed in a total of 20 patients during different surgical protocols. Implants were simultaneously inserted, and in case of sinus floor elevations 6 months later. Pre- and postoperative cone-beam computed tomographies were taken. Bone biopsies were harvested from augmented sides and processed for histomorphometric evaluation. Statistical Analysis: Averages and ranges were calculated for the percentage of newly formed bone, residual b...