The Effects of Exercise on BDNF Levels in Adolescents: A Systematic Review with Meta-Analysis
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Author/sMorais de Azevedo, Kesley Pablo; de Oliveira, Victor Hugo; Bandeira Silva de Medeiros, Gidyenne Christine; de Sousa Mata, Ádala Nayana; Ángel García, Daniel; [et al.]
Discipline/sActividad Física y Deporte
Ciencias de la Alimentación
Subject/sexercise; brain-derived neurotrophic factor; BDNF; adolescent; systematic review; meta-analysis
Abstract: The aim of this studywas to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10–19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive e ect in favor of the intervention, there were no significant differences (st...