Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Autor/es
Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; [et al.]Fecha
2020Disciplina/s
MedicinaResumen
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against
COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or
convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic
phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase
SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly,
SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that
SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe CO...