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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
dc.contributor.author | Sekine, Takuya | |
dc.contributor.author | Perez Potti, André | |
dc.contributor.author | Rivera Ballesteros, Olga | |
dc.contributor.author | Strålin, Kristoffer | |
dc.contributor.author | Gorin, Jean Baptiste | |
dc.contributor.author | Olsson, Annika | |
dc.contributor.author | Llewellyn Lacey, Sian | |
dc.contributor.author | Kamal, Habiba | |
dc.contributor.author | Bogdanovic, Gordana | |
dc.contributor.author | Muschiol, Sandra | |
dc.contributor.author | Wullimann, David | |
dc.contributor.author | Kammann, Tobias | |
dc.contributor.author | Emgård, Johanna | |
dc.contributor.author | Parrot, Tiphaine | |
dc.contributor.author | Folkesson, Elin | |
dc.contributor.author | Rooyackers, Olav | |
dc.contributor.author | Eriksson, Lars | |
dc.contributor.author | Henter, Jan Inge | |
dc.contributor.author | Sönnerborg, Anders | |
dc.contributor.author | Karolinska COVID-19 Study Group | |
dc.contributor.author | Rooyackers, Olav | |
dc.contributor.author | Eriksson, Lars | |
dc.contributor.author | Henter, Jan Inge | |
dc.contributor.author | Sönnerborg, Anders | |
dc.contributor.author | Allander, Tobias | |
dc.contributor.author | Albert, Jan | |
dc.contributor.author | Nielsen, Morten | |
dc.contributor.author | Klingström, Jonas | |
dc.contributor.author | Gredmark-Russ, Sara | |
dc.contributor.author | Björkström, Niklas | |
dc.contributor.author | Sandberg, Johan | |
dc.contributor.author | Price, David | |
dc.contributor.author | Ljunggren, Hans Gustaf | |
dc.date.accessioned | 2024-02-12T08:06:11Z | |
dc.date.available | 2024-02-12T08:06:11Z | |
dc.date.issued | 2020 | |
dc.identifier.uri | http://hdl.handle.net/10952/7330 | |
dc.description.abstract | SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19. | es |
dc.language.iso | en | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 | es |
dc.type | article | es |
dc.rights.accessRights | openAccess | es |
dc.journal.title | Cell | es |
dc.volume.number | 183 | es |
dc.issue.number | 1 | es |
dc.description.discipline | Medicina | es |
dc.identifier.doi | https://doi.org/10.1016/j.cell.2020.08.017 | es |