Effectiveness of Consumption of a Combination of Citrus Fruit Flavonoids and Olive Leaf Polyphenols to Reduce Oxidation of Low-Density Lipoprotein in Treatment-Naïve Cardiovascular Risk Subjects: A Randomized Double-Blind Controlled Study
Autor/es
Abellán Ruiz, María Salud; Luque Rubia, Antonio J.; Guillén Martínez, Daniel; Sánchez Macarro, Maravillas; Cánovas García, Fernando; [et al.]Fecha
2021-04-11Disciplina/s
Ciencias de la AlimentaciónEnfermería
Medicina
Materia/s
AntioxidantCardiovascular risk
Flavonoids
Food supplements
Oleuropeosides
Polyphenols
Resumen
Abstract: The aim of the study was to assess whether oral intake of a nutraceutical product (Cit-rolive™) could determine changes in low-density lipoprotein (LDL) oxidation and other param-eters of lipid metabolism and plasma atherogenic capacity. Citrolive™ is a commercial extract
obtained from the combination of citrus fruit flavonoids and olive leaf extracts. Twenty-three un-treated subjects (69.6% males, 30.4% females, mean age 41.9 9.4 years) with cardiovascular risk factors and a total cholesterol level >200 mg/dL and LDL cholesterol (LDL-C) > 130 mg/dL par-ticipated in a 3-month randomized double-blind controlled study. Participants in the intervention group (71.4% males, 28.6% females, mean age 42.7 9.7 years) consumed Citrolive™ (500 mg, two capsules/day), and controls (66.7% males, 33.3% females, mean age 40.6 9.4 years) received a matched placebo. At 3 months, oxidized LDL (ox-LDL) decreased significantly in the interven-tion group from 93.8 19.1 U/L to 62.8 28.7 ...