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dc.contributor.authorAbellán Ruiz, María Salud
dc.contributor.authorLuque Rubia, Antonio J.
dc.contributor.authorGuillén Martínez, Daniel
dc.contributor.authorSánchez Macarro, Maravillas
dc.contributor.authorCánovas García, Fernando
dc.contributor.authorCastillo Sánchez, Julián
dc.contributor.authorPérez Piñero, Silvia
dc.contributor.authorGarcía Muñoz, Ana María
dc.contributor.authorLópez Román, Francisco Javier
dc.date.accessioned2024-02-12T12:42:02Z
dc.date.available2024-02-12T12:42:02Z
dc.date.issued2021-04-11
dc.identifier.issnISSN: 2076-3921
dc.identifier.urihttp://hdl.handle.net/10952/7336
dc.description.abstractAbstract: The aim of the study was to assess whether oral intake of a nutraceutical product (Cit-rolive™) could determine changes in low-density lipoprotein (LDL) oxidation and other param-eters of lipid metabolism and plasma atherogenic capacity. Citrolive™ is a commercial extract obtained from the combination of citrus fruit flavonoids and olive leaf extracts. Twenty-three un-treated subjects (69.6% males, 30.4% females, mean age 41.9 9.4 years) with cardiovascular risk factors and a total cholesterol level >200 mg/dL and LDL cholesterol (LDL-C) > 130 mg/dL par-ticipated in a 3-month randomized double-blind controlled study. Participants in the intervention group (71.4% males, 28.6% females, mean age 42.7 9.7 years) consumed Citrolive™ (500 mg, two capsules/day), and controls (66.7% males, 33.3% females, mean age 40.6 9.4 years) received a matched placebo. At 3 months, oxidized LDL (ox-LDL) decreased significantly in the interven-tion group from 93.8 19.1 U/L to 62.8 28.7 U/L (p < 0.05), whereas the control group increased from 98.2 23.5 U/L to 105.7 21.9 U/L (p = 0.1). Between-group differences were also significant (p < 0.05). Similar findings in the ox-LDL/LDL-C ratio were observed. Serum paraoxonase activity (PON1) increased significantly in the intervention group from 64.5 15.6 U/L to 78.7 28.8 U/L (p < 0.05) but remained unchanged in controls. Consumption of Citrolive™ for 3months in treatment-naïve subjects with moderate risk of atherosclerosis was associated with a reduction in oxidized LDL-C and LDL-oxidase/LDL-C ratio as compared to controls.es
dc.language.isoenes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAntioxidantes
dc.subjectCardiovascular riskes
dc.subjectFlavonoidses
dc.subjectFood supplementses
dc.subjectOleuropeosideses
dc.subjectPolyphenolses
dc.titleEffectiveness of Consumption of a Combination of Citrus Fruit Flavonoids and Olive Leaf Polyphenols to Reduce Oxidation of Low-Density Lipoprotein in Treatment-Naïve Cardiovascular Risk Subjects: A Randomized Double-Blind Controlled Studyes
dc.typearticlees
dc.rights.accessRightsopenAccesses
dc.journal.titleantioxidantses
dc.volume.number10es
dc.issue.number589es
dc.description.disciplineCiencias de la Alimentaciónes
dc.description.disciplineEnfermeríaes
dc.description.disciplineMedicinaes
dc.identifier.doihttps://doi.org/10.3390/antiox10040589es


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional